KMID : 0191120100250010117
|
|
Journal of Korean Medical Science 2010 Volume.25 No. 1 p.117 ~ p.122
|
|
Efficacy and Safety of Tamsulosin for the Treatment of Non-neurogenic Voiding Dysfunction in Females: A 8-Week Prospective Study
|
|
Lee Kyu-Sung
Han Deok-Hyun Lee Young-Suk Choo Myung-Soo Yoo Tag-Keun Park Heung-Jae Yoon Ha-Na Jeong Hyeon Lee Sun-Ju Kim Ha-Young Park Won-Hee Han Deok-Hyun Lee Young-Suk Choo Myung-Soo Yoo Tag-Keun Park Heung-Jae Yoon Ha-Na Jeong Hyeon Lee Sun-Ju Kim Ha-Young Park Won-Hee
|
|
Abstract
|
|
|
We evaluated the therapeutic effects of tamsulosin for women with non-neurogenic voiding dysfunction. Women who had voiding dysfunctions for at least 3 months were included. Inclusion criteria were age ¡Ã18 yr, International Prostate Symptom Score (IPSS) of ¡Ã15, and maximum flow rate (Qmax) of ¡Ã12 mL/sec and/or postvoid residuals (PVR) of ¡Ã150 mL. Patients with neurogenic voiding dysfunction or anatomical bladder outlet obstruction were excluded. All patients were classified according to the Blaivas-Groutz nomogram as having no or mild obstruction (group A) or moderate or severe obstruction (group B). After 8 weeks of treatment, treatment outcomes and adverse effects were evaluated. One hundred and six patients were evaluable (70 in group A, 36 in group B). After treatments, mean IPSS, bother scores, Qmax, PVR, diurnal and nocturnal micturition frequencies and scored form of the Bristol Female Lower Urinary Tract Symptoms questionnaire (BFLUTS-SF) were changed significantly. Eighty-nine patients (84%) reported that the treatment was beneficial. The proportion of patients reported that their bladder symptoms caused "moderate to many severe problems" were significantly decreased. No significant difference were observed between the groups in terms of IPSS, bother score, Qmax, PVR, micturition frequency, and BFLUTS-SF changes. Adverse effects related to medication were dizziness (n=3), de novo stress urinary incontinence (SUI) (n=3), aggravation of underlying SUI (n=1), fatigue (n=1). Tamsulosin was found to be effective in female patients with voiding dysfunction regardless of obstruction grade.
|
|
KEYWORD
|
|
Urination Disorders, Female, Adrenergic alpha-Antagonists, Outcomes Assessment
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|
|